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Acute Myocardial Infarction: More commonly known as a heart attack.
ADAMTS13: An enzyme that cuts von Wille brand Factor (vWF) into smaller pieces, preventing unnecessary blood clotting.
Anemia: A condition in which the number of red blood cells is low. Patients with anemia most commonly experience fatigue (feeling tired)
Antibody: A type of protein that helps protect the body against infection. When antibodies recognize a specific foreign substance (such as viruses or bacteria) in the body, they bind to the substance to stop it from harming the body.
Enzyme: Enzymes are a type of protein. There are tens of thousands of different types of enzymes in the human body, each of which performs a specific job to help our bodies function. Some enzymes break molecules into smaller pieces, some join two molecules together while others help us digest our food.
Hemolytic anemia: A type of anemia caused by the destruction of red blood cells.
Immune-mediated TTP (iTTP): Another term to describe acquired TTP. It refers to the fact that TTP is caused by antibodies produced by the immune system.
Immunosuppressant / immunomodulatory: a type of medicine that suppresses the immune system. It is often used in autoimmune conditions, where the immune system is attacking healthy cells in the body.
Jaundice: A condition where the skin and the whites of the eyes look yellow.
Petechiae: Small, round spots that appear on the skin as a result of bleeding.
Plasma exchange therapy: The main treatment for people with TTP. It involves removing the plasma from the blood and replacing it with donated plasma.
Plasmapheresis: Another term for plasma exchange therapy.
Platelets: Platelets are one of the main components of the blood, and play a key role in forming blood clots to prevent bleeding.
Protein: Proteins are large molecules that play many essential roles in the body. Proteins carry out the chemical reactions that take place in cells, help our bodies fight infections, transmit messages between cells, transport molecules around the body and much more. There are many different types of proteins, including antibodies, enzymes and transport proteins.
Purpura: Refers to purple bruises caused by bleeding underneath the skin.
Thrombocytopenia / Thrombocytopenic: Refers to a condition in which the number of platelets in the blood is lower than normal.
Thrombosis / Thrombotic: Refers to the formation of a blood clot inside a blood vessel.
Ultra-large von Willebrand Factor multimers: These are the large molecules of von Willebrand factor that are present in patients with TTP.
von Willebrand Factor (vWF): A type of protein that is essential in the process of blood clotting. vWF is the substance that platelets attach to in order to form a clot.